Aminomethylphosphonic acid is a metabolite of glyphosate. Structure, properties, spectra, suppliers and links for: Aminomethylphosphonic acid, Aminomethylphosphonic acid (AMPA) is a weak organic acid with a phosphonic acid group. It is one of the primary degradation products of the herbicide Number‎: ‎


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AminoMethylPhosphonic acid (AMPA) in natural waters: Its sources, behavior and environmental fate.

We sought to determine whether glyphosate and its metabolite aminomethylphosphonic acid AMPA could be detected in milk and urine produced by lactating women and, if so, to quantify typical consumption by breastfed infants. Milk and urine samples were analyzed for glyphosate and AMPA with the use of highly sensitive liquid chromatography—tandem mass spectrometry methods validated for and optimized to each aminomethylphosphonic acid matrix.

Because of the complex nature of milk matrixes, these samples required more dilution before analysis than did urine, thus decreasing the aminomethylphosphonic acid of the assay in milk compared with aminomethylphosphonic acid.

By extension, our results therefore suggest that aminomethylphosphonic acid glyphosate exposure is not a health concern for breastfed infants. This study was registered at clinicaltrials.


Because these amino acids are not synthesized by humans, glyphosate would not be expected to have a physiological aminomethylphosphonic acid. Indeed, the human genome does not encode for 5-enolpyruvylshikimatephosphate synthase, and a large aminomethylphosphonic acid of epidemiologic and experimental literature supports the safety of glyphosate in mammals 56.

In addition, neither glyphosate nor its metabolite aminomethylphosphonic acid AMPA 8 seem to bioaccumulate in animal tissues 7 — 9.


In addition, most scientific evidence does not support contentions that glyphosate may cause cancer in humans, as recently concluded after a lengthy review by the European Food Standards Authority The US Environmental Protection Agency EPA has authorized the use of glyphosate as an herbicide aminomethylphosphonic acid noncrop and industrial areas since and in agriculture since The safety of glyphosate use as an herbicide is periodically re-evaluated, with the last federal review completed in Despite its long-standing track record for safety, decades of research have resulted in a vast body of literature related to the clearance and disposition of ingested glyphosate.

Several studies have also investigated urine glyphosate concentrations of humans exposed to glyphosate via diet and other environmental sources 1422 — There was no difference in urine glyphosate concentrations between children living in farm and nonfarm households Of particular interest to our research group is aminomethylphosphonic acid potential glyphosate exposure of infants during breastfeeding.

Because there have been to our knowledge no studies published in peer-reviewed journals reporting glyphosate concentrations in human milk, this study Aminomethylphosphonic acid was undertaken primarily to document typical glyphosate and AMPA concentrations in milk produced by lactating women living in the US Pacific Northwest—a highly productive agricultural region in which glyphosate-containing herbicides are routinely used Maternal urine samples were also collected and analyzed.

We aminomethylphosphonic acid that concentrations of glyphosate and AMPA in milk and urine would be low, if even detectable. It can reach shallow groundwater, but rarely managed to enter deep groundwater. AMPA is strongly adsorbed to soil particles and moves with the particles towards the stream in rainfall runoff.

In aminomethylphosphonic acid areas, AMPA comes from phosphonates and glyphosate in wastewater.

AminoMethylPhosphonic acid (AMPA) in natural waters: Its sources, behavior and environmental fate.

Sediments tend to accumulate AMPA, where it may be biodegraded. Airborne AMPA is not negligible, but does wash-out with heavy rainfall. AMPA is aminomethylphosphonic acid to be persistent and can be biologically degraded in soils aminomethylphosphonic acid sediments.

Limited photodegradation in waters exists. AMPA mainly has its sources in agricultural leachates, and urban wastewater effluents.